Combination of curcumin/curcuminoids and piperine from Piper nigrum extract has been clinically shown to increase the bioavailability of curcuminoids by almost 20 folds (1). Researchers reported the specific increase in bioavailability of curcumin itself and not its phase II metabolites. The rapid biotransformation of curcumin via phase II metabolism lowers the bioactivity of curcumin. Piperine is known to inhibit the formation of phase II metabolites by inhibiting hepatic and intestinal glucuronidation (2). Simultaneous consumption of 5 mg of piperine along with Curcuminoids has shown to increase the bioavailability of curcumin. In addition, the thermogenesis activity of piperine facilitates sustenance of the metabolic process and enables better absorption of nutrients in the intestine.[1, 2]
NFH Curcumin SAP is tested for curcumin I, demethoxycurcumin, and bisdemethoxycurcumin.
- Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Planta Med. 1998, 64 (4), 353-6.
- Singh J, Dubey RK, Atal CK. J. Pharmacol. Exp. Ther. 1986, 236 (2), 488-93.